Regulation of membrane band 3 Tyr-phosphorylation by proteolysis of p72 and possible involvement in senescence process
نویسندگان
چکیده
Luciana Bordin1, Cristina Fiore2, Marcantonio Bragadin3, Anna Maria Brunati1, and Giulio Clari1* Dipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy Dipartimento di Scienze Mediche Chirurgiche-Endocrinologia, Università di Padova, Via Ospedale 105, 35100 Padova, Italy Dipartimento di Scienze Ambientali, Università di Venezia, Calle Larga S. Marta 2137, 30123 Venezia, Italy *Correspondence address. Tel: þ39-49-8276113; Fax: þ39-49-8073310; E-mail: [email protected]
منابع مشابه
Regulation of membrane band 3 Tyr-phosphorylation by proteolysis of p72(Syk) and possible involvement in senescence process.
Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis that proteolytic activation of Syk kinase by conversion from 72 kDa (p72(Syk)) to...
متن کاملDifferential sorting of tyrosine kinases and phosphotyrosine phosphatases acting on band 3 during vesiculation of human erythrocytes.
One of the most intensively studied post-translational modifications of erythrocyte proteins is the phosphorylation of tyrosine residues of band 3, which is strictly regulated in vivo by PTKs (protein-tyrosine kinases) and PTPs (protein-phosphotyrosine phosphatases). Two PTKs (p72(syk) and p56/53(lyn)) and two PTP activities (PTP1B and SHPTP-2) have been immunologically identified so far in mat...
متن کاملInvolvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver.
Cell volume changes critically determine hepatic signal transduction and metabolism. Hepatocyte swelling by insulin contributes to p38(MAPK) activation leading to inhibition of autophagic proteolysis. Recently integrins were shown to sense hypoosmotic hepatocyte swelling. Here the role of integrins, Src, and focal adhesion kinase (FAK) in insulin signaling was investigated using the intact orga...
متن کاملOxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells.
Oxidative events involving band 3 (Anion Exchanger 1) have been associated with RBC (red blood cell) removal through binding of NAbs (naturally occurring antibodies); however, the underlying mechanism has been only partially characterized. In addition to inducing direct membrane protein oxidative modification, oxidative treatment specifically triggers the phosphorylation of band 3 tyrosine resi...
متن کاملRED CELLS Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes
Tyr phosphorylation of the multifunctional transmembrane protein band 3 has been implicated in several erythrocyte functions and disorders. We previously demonstrated that pervanadate treatment of human erythrocytes induces band-3 Tyr phosphorylation, which is catalyzed by the sequential action of tyrosine kinase Syk and tyrosine kinase(s) belonging to the Src family. In this study, we show tha...
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تاریخ انتشار 2009